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🧬FDA Guidance on Genomic Alterations in Food-Producing Animals

The Food and Drug Administration (FDA, Agency, or we) is announcing the availability of a draft guidance for industry (GFI) #251 entitled "Heritable Intentional Genomic Alterations in Animals of Food-Producing Species for Use as Models of Disease." This draft guidance, when finalized, will set forth FDA's policy regarding heritable intentional genomic alterations (IGAs) in animals of food- producing species, such as swine and rabbits, that are intended to be marketed for use as models of human or animal disease in biomedical research under contained and controlled conditions. The draft guidance describes the conditions under which we generally may not expect developers of IGAs in animal models of disease to submit an application to FDA's Center for Veterinary Medicine (CVM) or to get our approval before marketing their animals following CVM's prior review of risk factor data.

📦USPS Product Change Notice

The Postal Service gives notice of filing a request with the Postal Regulatory Commission to add a domestic shipping services contract to the list of Negotiated Service Agreements in the Mail Classification Schedule's Competitive Products List.

🏥Upcoming NIH Meeting on Grant Applications for Health Research

📦USPS Notice on Priority Mail and Ground Advantage Agreement Changes

The Postal Service gives notice of filing a request with the Postal Regulatory Commission to add a domestic shipping services contract to the list of Negotiated Service Agreements in the Mail Classification Schedule's Competitive Products List.

📦USPS Notice on Priority Mail Service Changes and Regulations

The Postal Service gives notice of filing a request with the Postal Regulatory Commission to add a domestic shipping services contract to the list of Negotiated Service Agreements in the Mail Classification Schedule's Competitive Products List.

📦Postal Service Notice

The Postal Service gives notice of filing a request with the Postal Regulatory Commission to add a domestic shipping services contract to the list of Negotiated Service Agreements in the Mail Classification Schedule's Competitive Products List.

🏡HUD Seeks Comments on Stepped and Tiered Rent Evaluation Study

HUD is seeking approval from the Office of Management and Budget (OMB) for the information collection described below. In accordance with the Paperwork Reduction Act, HUD is requesting comment from all interested parties on the proposed collection of information. The purpose of this notice is to allow for 60 days of public comment.

🌊Notice of Water Quality Certification Request for Northern States Power Company

🌍BLM's Response to Alaska Governor on Central Yukon Resource Management Plan

The Bureau of Land Management (BLM) is publishing this notice of the reasons for the BLM Director's determination to reject the Governor of Alaska's recommendations regarding the Central Yukon Proposed Resource Management Plan (RMP) and Final Environmental Impact Statement (EIS).

⚖️ITC Notice on Shapewear Complaint and Public Interest Solicitation

Notice is hereby given that the U.S. International Trade Commission has received a complaint entitled Certain Shapewear Garments and Components Thereof, DN 3799; the Commission is soliciting comments on any public interest issues raised by the complaint or complainant's filing pursuant to the Commission's Rules of Practice and Procedure.